Publications du laboratoire

Exploration de la cavité péritonéale / Evaluation de la carcinose

Audollent R, Eveno C, Dohan A, Sarda L, Jouvin I, Soyer P, Pocard M.
Pitfalls and mimickers on (18)F-FDG-PET/CT in peritoneal carcinomatosis from colorectal cancer: An analysis from 37 patients.
J Visc Surg. 2015 Nov;152(5):285-91. doi: 10.1016/j.jviscsurg.2015.06.003. Epub 2015 Jun 23.

Barat M, Soyer P, Eveno C, Dautry R, Perronne L, Guerrache Y, Boudiaf M, Pocard M, Dohan A.
The presence of cardiophrenic angle lymph nodes is not an indicator of peritoneal carcinomatosis from colorectal cancer on MDCT: Results of a case-control study.
Eur J Surg Oncol. 2016 Feb;42(2):266-72. doi: 10.1016/j.ejso.2015.11.011. Epub 2015 Nov 27.

Dohan A, Eveno C, Soyer P, Pocard M.
Focal fatty infiltration in Segment IV of the liver mimicking peritoneal carcinomatosis on CT and MR imaging.
J Visc Surg. 2014 Sep;151(4):319-21. doi: 10.1016/j.jviscsurg.2014.05.008. Epub 2014 Jun 25.

Dohan A, Hoeffel C, Soyer P, Jannot AS, Valette PJ, Thivolet A, Passot G, Glehen O, Rousset P.
Evaluation of the peritoneal carcinomatosis index with CT and MRI.
Br J Surg. 2017 Aug;104(9):1244-1249. doi: 10.1002/bjs.10527. Epub 2017 Apr 4.

Ladjici Y, Pocard M, Marteau P, Valleur P, Dray X.
No-incision (NOTES) versus single-incision (single-port) surgery for access to sites of peritoneal carcinomatosis: a back-to-back animal study.
Surg Endosc. 2012 Sep;26(9):2658-66. doi: 10.1007/s00464-012-2251-2. Epub 2012 Apr 5.

Ladjici Y, Dray X, Marteau P, Valleur P, Pocard M.
Flexible versus rigid single-port peritoneoscopy: a randomized controlled trial in a live porcine model followed by initial experience in human cadavers.
Surg Endosc. 2012 Sep;26(9):2651-7. doi: 10.1007/s00464-012-2218-3. Epub 2012 Ma

Jouvin I, Dohan A, Gergi P, Pocard M.
Intra-abdominal benign multicystic peritoneal mesothelioma.
J Visc Surg. 2014 Apr;151(2):155-7. doi: 10.1016/j.jviscsurg.2013.12.014. Epub 2014 Jan 14.

Najah H, Malgras B, Dohan A, Gronnier C, Eveno C, Pocard M.
The role of single-incision laparoscopic peritoneal exploration in the management of patients with peritoneal metastases.
Surg Endosc. 2020 May;34(5):2040-2049. doi: 10.1007/s00464-019-06984-8. Epub 2019 Jul 18.

Najah H, Jouvin I, Besbes S, Cifuentes D, Eveno C, Pocard M.
Specific computed virtual chromoendoscopy for detection of peritoneal carcinomatosis: an animal study.
Surg Endosc. 2017 Oct;31(10):4034-4043. doi: 10.1007/s00464-017-5442-z. Epub 2017 Mar 10.

Najah H, Lo Dico R, Dohan A, Marry L, Eveno C, Pocard M.
A feasibility study of the use of computed virtual chromoendoscopy for laparoscopic evaluation of peritoneal metastases.
Surg Endosc. 2017 Feb;31(2):743-751. doi: 10.1007/s00464-016-5028-1. Epub 2016 Jun 20. Erratum in: Surg Endosc. 2017 Feb;31(2):752.

Najah H, Lo Dico R, Grienay M, Dohan A, Dray X, Pocard M.
Single-incision flexible endoscopy (SIFE) for detection and staging of peritoneal carcinomatosis.
Surg Endosc. 2016 Sep;30(9):3808-15. doi: 10.1007/s00464-015-4682-z. Epub 2015 Dec

Thiry T, Dohan A, Naneix AL, Pocard M, Guerrache Y, Fazel A, Soyer P.
Diffuse abdominopelvic leiomyomatosis: CT and MR imaging findings with histopathological correlation.
Diagn Interv Imaging. 2014 Jan;95(1):105-8. doi: 10.1016/j.diii.2013.07.007. Epub 2013 Aug 29.
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Etude des mécanismes biologiques de la carcinose

Abdelkader Taibi, Rea Lo Dico, Rachid Kaci, Anne Laure Naneix, Brice Malgras, Muriel Mathonnet, Marc Pocard
Evaluation of a new histological grading system for assessing the response to chemotherapy of peritoneal metastases from colorectal cancer: A mouse model study
PMID: 31540756 DOI: 10.1016/j.ejso.2019.09.008

Martine Perrot-Applanat, Cynthia Pimpie, German Cano-Sancho, Jean Philippe Antignac, Marc Pocard
Detection of Persistent Organic Pollutants in Omental Adipose Tissue from Patients with Diffuse-Gastric Cancer: A Pilot Study
PMID: 34638358 PMCID: PMC8508119 DOI: 10.3390/cancers13194874
Free PMC article

Johanne Seguin, Cynthia Pimpie , Pétronille Roy, Chantal Al Sabbagh, Marc Pocard, Nathalie Mignet, Vincent Boudy
Combination of tumor cell anti-adhesion and anti-tumor effect to prevent recurrence after cytoreductive surgery in a mice model
PMID: 33727143 DOI: 10.1016/j.ejpb.2021.01.020

Ullah M, Aoudjeghout W, Pimpie C, Pocard M, Mirshahi M.
Mitosis in Cancer Cell Increases Immune Resistance via High Expression of HLA-G and PD-L1.
Cancers (Basel). 2020 Sep 18;12(9):2661. doi: 10.3390/cancers12092661. PMID: 32961872
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Ullah M, Meziani S, Shah S, Kaci R, Pimpie C, Pocard M, Mirshahi M.
Differentiation of cancer cells upregulates HLA‑G and PD‑L1.
Oncol Rep. 2020 Jun;43(6):1797-1804. doi: 10.3892/or.2020.7572. Epub 2020 Apr 1. PMID: 32236615
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Iman Aldybiat, Shahsoltan Mirshahi, Rashid Kaci, Cynthia Pimpie, Marc Pocard, Jeannette Soria, Massoud Mirshahi
Differentiation of cancer cells upregulates HLA‑G and PD‑L1
Published online on: April 1, 2020

Althawadi H, Alfarsi H, Besbes S, Mirshahi S, Ducros E, Rafii A, Pocard M, Therwath A, Soria J, Mirshahi M.
Activated protein C upregulates ovarian cancer cell migration and promotes unclottability of the cancer cell microenvironment.
Oncol Rep. 2015 Aug;34(2):603-9. doi: 10.3892/or.2015.4061. Epub 2015 Jun 15.

Besbes S, Attal R, Mirshahi S, Chidiac J, Mahé I, Pocard M, Soria J, Mirshahi M.
PO-47 - Microparticles derived from ovarian cancer cell line contained genomic and biologically active proteins, including tissue factor involved in coagulation.
Thromb Res. 2016 Apr;140 Suppl 1:S194. doi: 10.1016/S0049-3848(16)30180-3. Epub 2016 Apr 8.

Besbes S, Helfer H, Najah H, Fourgeaud C, Mirshahi S, Soria J, Pocard M, Ghedira I, Mirshahi M.
PO-13 - Production of a functional thrombopoietin by a human ovarian cancer cell line.
Thromb Res. 2016 Apr;140 Suppl 1:S181. doi: 10.1016/S0049-3848(16)30146-3. Epub 2016 Apr 8.

Besbes S, Shah S, Al-Dybiat I, Mirshahi S, Helfer H, Najah H, Fourgeaud C, Pocard M, Ghedira I, Soria J, Mirshahi M.
Thrombopoietin Secretion by Human Ovarian Cancer Cells.
Int J Cell Biol. 2017;2017:1873834. doi: 10.1155/2017/1873834. Epub 2017 Mar 30.

Di Benedetto M, Toullec A, Buteau-Lozano H, Abdelkarim M, Vacher S, Velasco G, Christofari M, Pocard M, Bieche I, Perrot-Applanat M.
MDA-MB-231 breast cancer cells overexpressing single VEGF isoforms display distinct colonisation characteristics.
Br J Cancer. 2015 Sep 1;113(5):773-85. doi: 10.1038/bjc.2015.267. Epub 2015 Jul 21.
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Eveno C, Broqueres-You D, Feron JG, Rampanou A, Tijeras-Raballand A, Ropert S, Leconte L, Levy BI, Pocard M.
Netrin-4 delays colorectal cancer carcinomatosis by inhibiting tumor angiogenesis.
Am J Pathol. 2011 Apr;178(4):1861-9. doi: 10.1016/j.ajpath.2010.12.019. Epub 2011 Feb 26.
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Jouvin I, Najah H, Pimpie C, Canet Jourdan C, Kaci R, Mirshahi M, Eveno C, Pocard M.
Reduction of carcinomatosis risk using icodextrin as a carrier solution of intraperitoneal oxaliplatin chemotherapy.
Eur J Surg Oncol. 2017 Jun;43(6):1088-1094. doi: 10.1016/j.ejso.2016.12.009. Epub 2017 Jan 9.

Mirshahi S, Pujade-Lauraine E, Soria C, Pocard M, Mirshahi M, Soria J.
Urokinase Antimetastatic Effects-Letter.
Cancer Res. 2016 Aug 15;76(16):4909. doi: 10.1158/0008-5472.CAN-16-0138.
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Pasquier J, Gosset M, Geyl C, Hoarau-Véchot J, Chevrot A, Pocard M, Mirshahi M, Lis R, Rafii A, Touboul C.
CCL2/CCL5 secreted by the stroma induce IL-6/PYK2 dependent chemoresistance in ovarian cancer.
Mol Cancer. 2018 Feb 19;17(1):47. doi: 10.1186/s12943-018-0787-z.
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Perrot-Applanat M, Vacher S, Pimpie C, Chemlali W, Derieux S, Pocard M, Bieche I.
Differential gene expression in growth factors, epithelial mesenchymal transition and chemotaxis in the diffuse type compared with the intestinal type of gastric cancer.
Oncol Lett. 2019 Jul;18(1):674-686. doi: 10.3892/ol.2019.10392. Epub 2019 May 21.
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Shah S, Pocard M, Mirshahi M.
Targeting the differentiation of gastric cancer cells (KATO‑III) downregulates epithelial‑mesenchymal and cancer stem cell markers.
Oncol Rep. 2019 Aug;42(2):670-678. doi: 10.3892/or.2019.7198. Epub 2019 Jun 12.
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Shah S, Fourgeaud C, Derieux S, Mirshahi S, Contant G, Pimpie C, Lo Dico R, Soria J, Pocard M, Mirshahi M.
The close relationship between heparanase and epithelial mesenchymal transition in gastric signet-ring cell adenocarcinoma.
Oncotarget. 2018 Sep 18;9(73):33778-33787. doi: 10.18632/oncotarget.26042. eCollection 2018 Sep 18.

Shahid S, Iman A, Matti U, Rachid K, Assaf A, Eveno C, Marc P, Massoud M.
Fibrin Deposit on the Peritoneal Surface Serves as a Niche for Cancer Expansion in Carcinomatosis Patients.
Neoplasia. 2019 Nov;21(11):1091-1101. doi: 10.1016/j.neo.2019.08.006. Epub 2019 Nov 14.
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Sidibe A, Ropraz P, Jemelin S, Emre Y, Poittevin M, Pocard M, Bradfield PF, Imhof BA.
Angiogenic factor-driven inflammation promotes extravasation of human proangiogenic monocytes to tumours.
Nat Commun. 2018 Jan 24;9(1):355. doi: 10.1038/s41467-017-02610-0.
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Taibi A, Lo Dico R, Kaci R, Naneix AL, Malgras B, Mathonnet M, Pocard M.
Evaluation of a new histological grading system for assessing the response to chemotherapy of peritoneal metastases from colorectal cancer: A mouse model study.
Eur J Surg Oncol. 2020 Jan;46(1):160-165. doi: 10.1016/j.ejso.2019.09.008. Epub 2019 Sep 12.

Touboul C, Lis R, Al Farsi H, Raynaud CM, Warfa M, Althawadi H, Mery E, Mirshahi M, Rafii A.
Mesenchymal stem cells enhance ovarian cancer cell infiltration through IL6 secretion in an amniochorionic membrane based 3D model.
J Transl Med. 2013 Jan 31;11:28. doi: 10.1186/1479-5876-11-28.
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Ullah M, Azazzen D, Kaci R, Benabbou N, Pujade Lauraine E, Pocard M, Mirshahi M.
High Expression of HLA-G in Ovarian Carcinomatosis: The Role of Interleukin-1β.
Neoplasia. 2019 Mar;21(3):331-342. doi: 10.1016/j.neo.2019.01.001. Epub 2019 Feb 22.
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Ullah M, Meziani S, Shah S, Kaci R, Pimpie C, Pocard M, Mirshahi M.
Differentiation of cancer cells upregulates HLA‑G and PD‑L1.
Oncol Rep. 2020 Apr 1. doi: 10.3892/or.2020.7572. [Epub ahead of print]

Vacher S, Castagnet P, Chemlali W, Lallemand F, Meseure D, Pocard M, Bieche I, Perrot-Applanat M.
High AHR expression in breast tumors correlates with expression of genes from several signaling pathways namely inflammation and endogenous tryptophan metabolism.
PLoS One. 2018 Jan 10;13(1):e0190619. doi: 10.1371/journal.pone.0190619. eCollection 2018.
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Traitement des patients porteurs de métastases péritonéales

Taibi A, Lo Dico R, Kaci R, Naneix AL, Mathonnet M, Pocard M.
Impact of preoperative chemotherapy on the histological response of patients with peritoneal metastases from colorectal cancer according to peritoneal regression grading score (PRGS) and TRG.
Surg Oncol. 2020 Jun;33:158-163. doi: 10.1016/j.suronc.2020.02.014. Epub 2020 Feb 15. PMID: 32561082

Lo Dico R, Faron M, Yonemura Y, Glehen O, Pocard M, Sardi A, Hübner M, Baratti D, Liberale G, Kartheuser A, de Hingh I, Sugarbaker P, Ceelen W, Moran B, Robella M, Quenet F, Sideris L, Goere D, Limbert M, Sammartino P, Morris D; PSOGI Working Group
Combined liver resection and cytoreductive surgery with HIPEC for metastatic colorectal cancer: Results of a worldwide analysis of 565 patients from the Peritoneal Surface Oncology Group International (PSOGI).
BIG RENAPE Working Group. Eur J Surg Oncol. 2020 Aug 26:S0748-7983(20)30666-1.

Martin Hübner, Shigeki Kusamura, Laurent Villeneuve, Ahmed Al-Niaimi, Mohammad Alyami, Konstantin Balonov, John Bell, Robert Bristow, Delia Cortés Guiral, Anna Fagotti, Luiz Fernando R. Falcão, Olivier Glehen, Laura Lambert, Lloyd Mack, Tino Muenster, Pompiliu Piso, Marc Pocard, Beate Rau, Olivia Sgarbura, S.P. Somashekkar, Anupama Wadhwa, Alon Altman, William Fawcett, Jula Veerapong, Gregg Nelson
Guideline for Perioperative Care for Cytoreductive Surgery (CRS) with or without Hyperthermic IntraPEritoneal Chemotherapy (HIPEC): Enhanced Recovery After Surgery (ERAS®) Society Recommendations; Part I and Part II

Published:August 12, 2020DOI:

Dahbia Djelil, Anthony Dohan and Marc Pocard
Peritoneal pseudomyxoma after incomplete appendectomy
DOI: | Published online: 20 Aug 2020
Pleura and Peritoneum | Volume 5: Issue 3

Abboud K, André T, Brunel M, Ducreux M, Eveno C, Glehen O, Goéré D, Gornet JM, Lefevre JH, Mariani P, Pinto A, Quenet F, Sgarbura O, Ychou M, Pocard M.
Management of colorectal peritoneal metastases: Expert opinion.
J Visc Surg. 2019 Oct;156(5):377-379. doi: 10.1016/j.jviscsurg.2019.08.002. Epub 2019 Aug 26.
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Barat M, Soyer P, Eveno C, Dautry R, Perronne L, Guerrache Y, Boudiaf M, Pocard M, Dohan A.
The presence of cardiophrenic angle lymph nodes is not an indicator of peritoneal carcinomatosis from colorectal cancer on MDCT: Results of a case-control study.
Eur J Surg Oncol. 2016 Feb;42(2):266-72. doi: 10.1016/j.ejso.2015.11.011. Epub 2015 Nov 27.

Barral M, El Sanharawi I, Eveno C, Dohan A, Launay JM, Lo Dico R, Pocard M, Bonnin P.
Post-operative wall shear stress in the superior mesenteric artery: Biomarker of long term outcome in patients with residual disease after incomplete cytoreductive surgery for pseudomyxoma peritonei.
Eur J Surg Oncol. 2019 Sep;45(9):1727-1733. doi: 10.1016/j.ejso.2019.03.001. Epub 2019 Mar 6.

Bouquot M, Dohan A, Gayat E, Barat M, Glehen O, Pocard M, Rousset P, Eveno C.
Prediction of Resectability in Pseudomyxoma Peritonei with a New CT Score.
Ann Surg Oncol. 2018 Mar;25(3):694-701. doi: 10.1245/s10434-017-6275-7. Epub 2017 Nov 30.

Eveno C, Passot G, Goéré D, Soyer P, Gayat E, Glehen O, Elias D, Pocard M.
Bevacizumab doubles the early postoperative complication rate after cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (HIPEC) for peritoneal carcinomatosis of colorectal origin.
Ann Surg Oncol. 2014 Jun;21(6):1792-800. doi: 10.1245/s10434-013-3442-3. Epub 2013 Dec 15.

Mercier F, Dagbert F, Pocard M, Goéré D, Quenet F, Wernert R, Dumont F, Brigand C, Passot G, Glehen O; RENAPE Network.
Recurrence of pseudomyxoma peritonei after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy.
BJS Open. 2018 Sep 27;3(2):195-202. doi: 10.1002/bjs5.97. eCollection 2019 Apr.
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Malgras B, Gayat E, Aoun O, Lo Dico R, Eveno C, Pautrat K, Delhorme JB, Passot G, Marchal F, Sgarbura O, Ferron G, Goéré D, Andre T, Pocard M; RENAPE Network.
Impact of Combination Chemotherapy in Peritoneal Mesothelioma Hyperthermic Intraperitoneal Chemotherapy (HIPEC): The RENAPE Study.
Ann Surg Oncol. 2018 Oct;25(11):3271-3279. doi: 10.1245/s10434-018-6631-2. Epub 2018 Jul 5.

Osseis M, Weyrech J, Gayat E, Dagois S, Lo Dico R, Pocard M, Eveno C.
Epidural analgesia combined with a comprehensive physiotherapy program after Cytoreductive Surgery and HIPEC is associated with enhanced post-operative recovery and reduces intensive care unit stay: A retrospective study of 124 patients.
Eur J Surg Oncol. 2016 Dec;42(12):1938-1943. doi: 10.1016/j.ejso.2016.06.390. Epub 2016 Jun 27.

Pocard M.
Exploratory laparoscopy for carcinomatosis: discard that quiver full of trocars and use just one!
J Visc Surg. 2015 Jun;152(3):147-8. doi: 10.1016/j.jviscsurg.2015.04.004. Epub 2015 May 28.

Robieux L, Karsenti L, Pocard M, Flahault C.
Let's talk about empathy!
Patient Educ Couns. 2018 Jan;101(1):59-66. doi: 10.1016/j.pec.2017.06.024. Epub 2017 Jun 19.

Voron T, Eveno C, Jouvin I, Beaugerie A, Lo Dico R, Dagois S, Soyer P, Pocard M.
Cytoreductive surgery with a hyperthermic intraperitoneal chemotherapy program: Safe after 40 cases, but only controlled after 140 cases.
Eur J Surg Oncol. 2015 Dec;41(12):1671-7. doi: 10.1016/j.ejso.2015.09.005. Epub 2015 Sep 25.

Nouvelles technologies et développements futurs du laboratoire en oncologie

Al Dybiat I, Mirshahi S, Belalou M, Abdelhamid D, Shah S, Ullah M, Soria J, Pocard M, Mirshahi M.
Injured tissues favor cancer cell implantation via fibrin deposits on scar zones.
Neoplasia. 2020 Dec;22(12):809-819. doi: 10.1016/j.neo.2020.09.006. Epub 2020 Nov 3.PMID: 33152619
Free PMC article.
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Martellotto S, Maillot C, Villeneuve L, Eveno C, Sgarbura O, Pocard M
Restricted access to innovative surgical technique related to a specific training, is it ethical? Example of the PIPAC procedure. A systematic review and an experts survey.
Int J Surg. 2020 Nov;83:235-245.

Iman Al Dybiat , Alibi Baitukha , Cynthia Pimpie , Rachid Kaci , Marc Pocard , Farzaneh Arefi Khonsari and Massoud Mirshahi
Multi-nanolayer drug delivery using radiofrequency plasma technology
BMC Cancer volume 20, Article number: 565 (2020)

Baitukha A, Al-Dybiat I, Valinataj-Omran A, Pulpytel J, Pocard M, Mirshahi M, Arefi-Khonsari F.
Optimization of a low pressure plasma process for fabrication of a Drug Delivery System (DDS) for cancer treatment.
Mater Sci Eng C Mater Biol Appl. 2019 Dec;105:110089. doi: 10.1016/j.msec.2019.110089.
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Baitukha A, Al-Dybiat I, Valinataj-Omran A, Pulpytel J, Pocard M, Mirshahi M, Arefi-Khonsari F.
Low pressure plasma processing of collagen membranes for anticancer drug delivery.
Journal of Material Sciences & Engineering 2018 ;7 :1000499
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Bhatt S, Valamanesh F, Pulpytel J, Lo Dico R, Baiyukha A, Al-Dybiat I, Pocard M, Arefi-Khonsari F, Mirshahi M.
Radio-frequency plasma polymerized biodegradable carrier for in vivo release of cis-platinum.
Oncotarget. 2016 Sep 6;7(36):58121-58132. doi: 10.18632/oncotarget.10932.
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Eveno C, Haidara A, Ali I, Pimpie C, Mirshahi M, Pocard M.
Experimental pharmacokinetics evaluation of chemotherapy delivery by PIPAC for colon cancer: first evidence for efficacy.
Pleura Peritoneum. 2017 Jun 1;2(2):103-109. doi: 10.1515/pp-2017-0015. Epub 2017 May 25.
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Julien S, Merino-Trigo A, Lacroix L, Pocard M, Goéré D, Mariani P, Landron S, Bigot L, Nemati F, Dartigues P, Weiswald LB, Lantuas D, Morgand L, Pham E, Gonin P, Dangles-Marie V, Job B, Dessen P, Bruno A, Pierré A, De Thé H, Soliman H, Nunes M, Lardier G, Calvet L, Demers B, Prévost G, Vrignaud P, Roman-Roman S, Duchamp O, Berthet C.
Characterization of a large panel of patient-derived tumor xenografts representing the clinical heterogeneity of human colorectal cancer.
Clin Cancer Res. 2012 Oct 1;18(19):5314-28. doi: 10.1158/1078-0432.CCR-12-0372. Epub 2012 Jul 23.
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Kurbonov U, Davlatov A, Janobilova S, Kurbanov Z, Mirshahi M.
The Use of Temporoparietal Fascia Flap for Surgical Treatment of Traumatic Auricle Defects.
Plast Reconstr Surg Glob Open. 2018 May 2;6(5):e1741. doi: 10.1097/GOX.0000000000001741. eCollection 2018 May.
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Laemmel E, Segal N, Mirshahi M, Azzazene D, Le Marchand S, Wybier M, Vicaut E, Laredo JD.
Deleterious Effects of Intra-arterial Administration of Particulate Steroids on Microvascular Perfusion in a Mouse Model.
Radiology. 2016 Jun;279(3):731-40. doi: 10.1148/radiol.2015142746. Epub 2016 Jan 13.

Malgras B, Brullé L, Lo Dico R, El Marjou F, Robine S, Therwath A, Pocard M.
Insertion of a Stent in Obstructive Colon Cancer Can Induce a Metastatic Process in an Experimental Murine Model.
Ann Surg Oncol. 2015 Dec;22 Suppl 3:S1475-80. doi: 10.1245/s10434-015-4588-y. Epub 2015 May 9.

Marhic A, Tremblay JF, Kaci R, André T, Eveno C, Pocard M.
Molecular analysis of sentinel lymph node in colon carcinomas by one-step nucleic acid amplification (OSNA) reduces time to adjuvant chemotherapy interval.
Dig Liver Dis. 2017 Aug;49(8):924-928. doi: 10.1016/j.dld.2017.05.017. Epub 2017 May 30.

Miailhe G, Arfi A, Mirshahi M, Eveno C, Pocard M, Touboul C.
A new animal model for hyperthermic intraperitoneal chemotherapy (HIPEC) in tumor-bearing mice in the treatment of peritoneal carcinomatosis of ovarian origin.
J Visc Surg. 2018 Jun;155(3):183-189. doi: 10.1016/j.jviscsurg.2017.10.008. Epub 2017 Nov 3.

Pinto A, Pocard M.
Photodynamic therapy and photothermal therapy for the treatment of peritoneal metastasis: a systematic review.
Pleura Peritoneum. 2018 Dec 18;3(4):20180124. doi: 10.1515/pp-2018-0124. eCollection 2018 Dec 1. Review.
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Autres publications scientifiques du laboratoire en oncologie

Attieh Y, Clark AG, Grass C, Richon S, Pocard M, Mariani P, Elkhatib N, Betz T, Gurchenkov B, Vignjevic DM.
Cancer-associated fibroblasts lead tumor invasion through integrin-β3-dependent fibronectin assembly.
J Cell Biol. 2017 Nov 6;216(11):3509-3520. doi: 10.1083/jcb.201702033. Epub 2017 Sep 20.

Azzazene D, Al Thawadi H, Al Farsi H, Besbes S, Geyl C, Mirshahi S, Pardo J, Faussat AM, Jeannette S, Therwath A, Pujade-Lauraine E, Mirshahi M.
Plasma endothelial protein C receptor influences innate immune response in ovarian cancer by decreasing the population of natural killer and TH17 helper cells.
Int J Oncol. 2013 Oct;43(4):1011-8. doi: 10.3892/ijo.2013.2021. Epub 2013 Jul 18.
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Benabbou N, Mirshahi P, Bordu C, Faussat AM, Tang R, Therwath A, Soria J, Marie JP, Mirshahi M.
A subset of bone marrow stromal cells regulate ATP-binding cassette gene expression via insulin-like growth factor-I in a leukemia cell line.
Int J Oncol. 2014 Oct;45(4):1372-80. doi: 10.3892/ijo.2014.2569. Epub 2014 Jul 29.
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Benabbou N, Mirshahi P, Cadillon M, Soria J, Therwath A, Mirshahi M.
Hospicells promote upregulation of the ATP-binding cassette genes by insulin-like growth factor-I via the JAK2/STAT3 signaling pathway in an ovarian cancer cell line.
Int J Oncol. 2013 Sep;43(3):685-94. doi: 10.3892/ijo.2013.2017. Epub 2013 Jul 15.
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Besbes S, Althawadi H, Alfarsi H, Mirshahi S, Tang R, Fava F, Pardo J, Huessler EM, Galtier T, Ghedira I, Soria J, Marie JP, Mirshahi M.
Endothelial protein C receptor gene 6936A/G single-nucleotide polymorphism as a possible biomarker of thrombotic risk in acute myeloid leukemia.
Mol Clin Oncol. 2015 Nov;3(6):1280-1284. Epub 2015 Sep 8.
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Di Benedetto M, Toullec A, Buteau-Lozano H, Abdelkarim M, Vacher S, Velasco G, Christofari M, Pocard M, Bieche I, Perrot-Applanat M.
MDA-MB-231 breast cancer cells overexpressing single VEGF isoforms display distinct colonisation characteristics.
Br J Cancer. 2015 Sep 1;113(5):773-85. doi: 10.1038/bjc.2015.267. Epub 2015 Jul 21.
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Dohan A, Lousquy R, Eveno C, Goere D, Broqueres-You D, Kaci R, Lehmann-Che J, Launay JM, Soyer P, Bonnin P, Pocard M.
Orthotopic animal model of pseudomyxoma peritonei: An in vivo model to test anti-angiogenic drug effects.
Am J Pathol. 2014 Jul;184(7):1920-9. doi: 10.1016/j.ajpath.2014.03.004. Epub 2014 May 9.
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El Sheikh Saad H, Toullec A, Vacher S, Pocard M, Bieche I, Perrot-Applanat M.
In utero and lactational exposure to vinclozolin and genistein induces genomic changes in the rat mammary gland.
J Endocrinol. 2013 Jan 18;216(2):245-63. doi: 10.1530/JOE-12-0395. Print 2013 Feb.

Eveno C, Hainaud P, Rampanou A, Bonnin P, Bakhouche S, Dupuy E, Contreres JO, Pocard M.
Proof of prometastatic niche induction by hepatic stellate cells.
J Surg Res. 2015 Apr;194(2):496-504. doi: 10.1016/j.jss.2014.11.005. Epub 2014 Nov 10.

Fourgeaud C, Derieux S, Mirshahi S, Besbes S, Chidiac J, Mahé I, Contant G, Pocard M, Soria J, Mirshahi M.         
PO-23 - Expression of heparanase in cancer as biomarker of malignancies: overexpression in an aggressive, poor survival gastric cancer "gastric signet ring cell carcinoma" compared with that of other gastric cancers.
Thromb Res. 2016 Apr;140 Suppl 1:S184-5. doi: 10.1016/S0049-3848(16)30156-6. Epub 2016 Apr 8.

Kaci R, Shah S, Lo Dico R, Brouland J-P, Therwath A, Pocard M, Mirshahi M.
Neural signature expressed by cells from ovarian carcinoma (A case report).
Immunochem Immunopathol 2015

Lim C, Broqueres-You D, Brouland JP, Merkulova-Rainon T, Faussat AM, Hilal R, Rouquie D, Eveno C, Audollent R, Levy BI, Pocard M.
Hepatic ischemia-reperfusion increases circulating bone marrow-derived progenitor cells and tumor growth in a mouse model of colorectal liver metastases.
J Surg Res. 2013 Oct;184(2):888-97. doi: 10.1016/j.jss.2013.04.069. Epub 2013 May 21.

Lo Dico R, Tijeras-Raballand A, Bonnin P, Launay JM, Kaci R, Pimpie C, Malgras B, Dohan A, Lo Dico GM, Pocard M.
Hepatectomy increases metastatic graft and growth in an immunocompetent murine model of peritoneal metastases.
Eur J Surg Oncol. 2018 Jun;44(6):784-791. doi: 10.1016/j.ejso.2018.01.096. Epub 2018 Jan 31.

Meunier K, Ferron M, Calmel C, Fléjou JF, Pocard M, Praz F.
Impact of MLH1 expression on tumor evolution after curative surgical tumor resection in a murine orthotopic xenograft model for human MSI colon cancer.
Genes Chromosomes Cancer. 2017 Sep;56(9):681-690. doi: 10.1002/gcc.22472. Epub 2017 Jun 12.

Mirshahi S, Soria C, Kouchakji B, Kierzek G, Borg JY, Varin R, Chidiac J, Drouet L, Mirshahi M, Soria J.
New combinational assay using soluble fibrin and d-dimer determinations: a promising strategy for identifying patients with suspected venous thromboembolism.
PLoS One. 2014 Mar 24;9(3):e92379. doi: 10.1371/journal.pone.0092379. eCollection 2014.
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Perrot-Applanat M, Kolf-Clauw M, Michel C, Beausoleil C.
Alteration of mammary gland development by bisphenol a and evidence of a mode of action mediated through endocrine disruption.
Mol Cell Endocrinol. 2018 Nov 5;475:29-53. doi: 10.1016/j.mce.2018.06.015. Epub 2018 Jul 23. Review.

Perrot-Applanat M.
VEGF isoforms.
Cell Adh Migr. 2012 Nov-Dec;6(6):526-7. doi: 10.4161/cam.23256. Epub 2012 Nov 1. No abstract available.
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Perrot-Applanat M, Di Benedetto M.
Autocrine functions of VEGF in breast tumor cells: adhesion, survival, migration and invasion.
Cell Adh Migr. 2012 Nov-Dec;6(6):547-53. doi: 10.4161/cam.23332. Epub 2012 Nov 1.
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Phrakonkham P, Brouland JP, Saad Hel S, Bergès R, Pimpie C, Pocard M, Canivenc-Lavier MC, Perrot-Applanat M.
Dietary exposure in utero and during lactation to a mixture of genistein and an anti-androgen fungicide in a rat mammary carcinogenesis model.
Reprod Toxicol. 2015 Jul;54:101-9. doi: 10.1016/j.reprotox.2014.05.016. Epub 2014 Jun 8.

Soria J, Mirshahi S, Mirshahi SQ, Varin R, Pritchard LL, Soria C, Mirshahi M.
Fibrinogen αC domain: Its importance in physiopathology.
Res Pract Thromb Haemost. 2019 Feb 15;3(2):173-183. doi: 10.1002/rth2.12183. eCollection 2019 Apr. Review.
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Autres publications scientifiques du laboratoire en angiogenèse et hémodynamique

Audollent R, Eveno C, Contreres JO, Hainaud P, Rampanou A, Dupuy E, Brouland JP, Pocard M.
Bone marrow-derived endothelial and hematopoietic precursors cells enhance the metastasis of colon cancer in an orthotopic murine model.
Int J Cancer. 2011 Nov 1;129(9):2304-5. doi: 10.1002/ijc.25882.
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Barral M, Raballand A, Dohan A, Soyer P, Pocard M, Bonnin P.
Preclinical Assessment of the Efficacy of Anti-Angiogenic Therapies in Hepatocellular Carcinoma.
Ultrasound Med Biol. 2016 Feb;42(2):438-46. doi: 10.1016/j.ultrasmedbio.2015.10.012. Epub 2015 Nov 28.

Becherirat S, Valamanesh F, Karimi M, Faussat AM, Launay JM, Pimpie C, Therwath A, Pocard M.
Discontinuous Schedule of Bevacizumab in Colorectal Cancer Induces Accelerated Tumor Growth and Phenotypic Changes.
Transl Oncol. 2018 Apr;11(2):406-415. doi: 10.1016/j.tranon.2018.01.017. Epub 2018 Feb 20.
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Bonnin P, Pansiot J, Baud O, Charriaut-Marlangue C.
Prostaglandin E1-Mediated Collateral Recruitment Is Delayed in a Neonatal Rat Stroke Model.
Int J Mol Sci. 2018 Sep 30;19(10). pii: E2995. doi: 10.3390/ijms19102995.
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Bonnin P, Pansiot J, Paven E, Eloi M, Renolleau S, Baud O, Leger PL, Charriaut-Marlangue C.
Controlled arterial reflow after ischemia induces better outcomes in the juvenile rat brain.
J Cereb Blood Flow Metab. 2017 Sep;37(9):3091-3096. doi: 10.1177/0271678X17719614. Epub 2017 Jul 11.
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Bonnin P, Pournaras JA, Makowiecka K, Krivosic V, Kedra AW, Le Gargasson JF, Gaudric A, Levy BI, Cohen YS, Tadayoni R, Massin P.
Ultrasound assessment of ocular vascular effects of repeated intravitreal injections of ranibizumab for wet age-related macular degeneration.
Acta Ophthalmol. 2014 Aug;92(5):e382-7. doi: 10.1111/aos.12356. Epub 2014 Feb 7.
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Dohan A, Barral M, Eveno C, Lo Dico R, Kaci R, Pasteur-Rousseau A, Soyer P, Pocard M, Bonnin P.
Prediction of clinical outcome using blood flow volume in the superior mesenteric artery in patients with pseudomyxoma peritonei treated by cytoreductive surgery.
Eur J Surg Oncol. 2017 Oct;43(10):1932-1938. doi: 10.1016/j.ejso.2017.05.015. Epub 2017 May 25.

Lim C, Broqueres-You D, Brouland JP, Merkulova-Rainon T, Faussat AM, Hilal R, Rouquie D, Eveno C, Audollent R, Levy BI, Pocard M.
Hepatic ischemia-reperfusion increases circulating bone marrow-derived progenitor cells and tumor growth in a mouse model of colorectal liver metastases.
J Surg Res. 2013 Oct;184(2):888-97. doi: 10.1016/j.jss.2013.04.069. Epub 2013 May 21.

Eveno C, Le Henaff C, Audollent R, Soyer P, Rampanou A, Nemeth J, Brouland JP, Dupuy E, Pocard M, Bonnin P.
Tumor and non-tumor liver angiogenesis is traced and evaluated by hepatic arterial ultrasound in murine models.
Ultrasound Med Biol. 2012 Jul;38(7):1195-204. doi: 10.1016/j.ultrasmedbio.2012.03.004. Epub 2012 Apr 27.

Eveno C, Contreres JO, Hainaud P, Nemeth J, Dupuy E, Pocard M.
Netrin-4 overexpression suppresses primary and metastatic colorectal tumor progression.
Oncol Rep. 2013 Jan;29(1):73-8. doi: 10.3892/or.2012.2104. Epub 2012 Oct 23.

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